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Jan282019

The Holy Grail of Orthopedic Surgery: Mesenchymal Regenerative Medicines—Their Current Uses and Potential Applications

Research StudiesBy Regenerative Medicine Therapy Clinic January 28, 2019

Only select tissues and organs are able to spontaneously regenerate after disease or trauma, and this regenerative capacity diminishes over time. Human regenerative medicine research explores therapeutic regenerative approaches to treat various conditions. Mesenchymal regenerative medicines (MSCs) are derived from adult regenerative medicines; they are multipotent and exert anti-inflammatory and immunomodulatory effects. They can differentiate into multiple cell types of the mesenchyme, for example, endothelial cells, osteoblasts, chondrocytes, fibroblasts, tenocytes, vascular smooth muscle cells, and sarcomere muscular cells. MSCs are easily obtained and can be cultivated and expanded in vitro; thus, they represent a promising and encouraging treatment approach in orthopedic surgery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494105/
Roberto Berebichez-Fridman, Ricardo Gómez-García, Julio Granados-Montiel, Enrique Berebichez-Fastlicht, Anell Olivos-Meza, Julio Granados, Cristina Velasquillo, and Clemente Ibarra

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Jan282019

Mesenchymal Regenerative Medicines in Tissue Repair

Research StudiesBy Regenerative Medicine Therapy Clinic January 28, 2019

The advent of mesenchymal regenerative medicine (MSC)-based therapies for clinical therapeutics has been an exciting and new innovation for the treatment of a variety of diseases associated with inflammation, tissue damage, and subsequent regeneration and repair. Application-based ability to measure MSC potency and fate of the cells post-MSC therapy are the variables that confound the use of MSCs therapeutics in human diseases. An evaluation of MSC function and applications with attention to detail in the preparation as well as quality control and quality assurance are only as good as the assays that are developed. In vivo measures of efficacy and potency require an appreciation of the overall pathophysiology of the model and standardization of outcome measures. The new concepts of how MSC’s participate in the tissue regeneration and wound repair process and further, how this is impacted by estimates of efficacy and potency are important new topics. In this regard, this chapter will review some of the in vitro and in vivo assays for MSC function and activity and their application to the clinical arena.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761350/
Amy M. DiMarino, Arnold I. Caplan, and Tracey L. Bonfield

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Jan282019

Regenerative Medicine for Treatment of Knee Osteoarthritis

Intra‐Articular Injection of Mesenchymal Regenerative Medicines for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial

Knee Research, Osteoarthritis, Research StudiesBy Regenerative Medicine Therapy Clinic January 28, 2019

Mesenchymal regenerative medicines (MSCs) are known to have a potential for articular cartilage regeneration. However, most studies focused on focal cartilage defect through surgical implantation. For the treatment of generalized cartilage loss in osteoarthritis, an alternative delivery strategy would be more appropriate. The purpose of this study was to assess the safety and efficacy of intra‐articular injection of autologous adipose tissue derived MSCs (AD‐MSCs) for knee osteoarthritis. We enrolled 18 patients with osteoarthritis of the knee and injected AD MSCs into the knee. The phase I study consists of three dose‐escalation cohorts; the low‐dose (1.0 × 107 cells), mid‐dose (5.0 × 107), and high‐dose (1.0 × 108) group with three patients each.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.1634
Chris Hyunchul Jo, Young Gil Lee, Won Hyoung Shin, Hyang Kim, Jee Won Chai, Eui Cheol Jeong, Ji Eun Kim, Hackjoon Shim, Ji Sun Shin, Il Seob Shin, Jeong Chan Ra, Sohee Oh, and Kang Sup Yoon

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Jan282019

Mesenchymal regenerative medicines in osteoarthritis

Osteoarthritis, Research StudiesBy Regenerative Medicine Therapy Clinic January 28, 2019

Accumulating evidence indicates that every tissue contains regenerative medicines. Our understanding of the biology of regenerative medicines reveals that these cell populations have a critical role in the homeostasis and repair of tissues. Besides the local regenerative medicine niches, additional compartments in the body such as the bone marrow may serve as reservoirs for regenerative medicine populations. On more extensive tissue damage, and guided by local repair responses, “reparative” cell populations are mobilized from more distant regenerative medicine reservoirs and migrate to the site of injury, thereby contributing in many aspects of local tissue repair.
https://journals.lww.com/co-rheumatology/Abstract/2004/09000/Mesenchymal_stem_cells_in_osteoarthritis.19.aspx
Frank P. Luyten

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